I found a patent Methods of storing information using nucleic acids (link goes to Google Patents). After cursory reading it seems to me it describes the content of the scientific article Next-Generation Digital Information Storage in DNA published in journal Science. The supplementary materials which illustrate the procedure are available publicly.
They take a computer file, split it into chunks of 96 bits, replace zero bits with either A or C nucleotide and ones with either G or T. Then they prepend 19 nucleotides to encode the position of the fragment in the source file and finally a 22 bp sequences at the beginning and end to allow them to amplify the segments using PCR. This is all that is to the encoding scheme.
It seems to me too simple to be actually patentable. Is it?
- A method of storing information using nucleotides comprising
converting a format of information into a plurality of bit sequences of a bit stream with each having a corresponding bit barcode,
converting the plurality of bit sequences to a plurality of corresponding oligonucleotide sequences using one bit per base encoding,
synthesizing the plurality of corresponding oligonucleotide sequences, and storing the synthesized plurality of corresponding oligonucleotide sequences.