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Can I build a new research methodology or application that leverages an existing research methodology?

I would like to leverage an existing (and patented) research methodology, but use it in a different way. The current patented methodology relies on a specific process of humans prescribing assignments ...
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My patent expired before I successfully marketed it, can I successfully market it?

My patent expired some years back. I was not knowledgeable as to how to market it back then. Could I create a new version of it and patent that? I know I could easily market it, as is, on Youtube now. ...