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Prior art which discloses less than 2mg of prednisone used for treatment of arthritis

Which is the closest prior art for this patent which discloses less than 2mg of prednisone used for treatment of arthritis? The list of documents in hit results includes US6677326 patent European ...
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If a medicine is listed in an ancient book, can it still be patented?

I have seen many patents related to use of herbs in medicines, like some homemade remedy for cough syrup etc. A large number of such remedies are already listed in many ancient medical books, one ...