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Prior Art search

What are the best way to search closest prior art and how to identify closest prior arts from prosecution file history for pharmaceutical patents.
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Mobile App Patent

I would like to know, if a basic search of patent database will give me an idea on whether my idea is patent-able? or I need to perform any specific patentiblity search?
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Partial disclosure of EP2709017A1 before the patent filing date of Sep 14, 2012

In reference to the patent: EP2709017A1 the summary of the invention states: "the invention provides a device for controlling the access to a cache structure comprising multiple cache sets during the ...