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Can a patent issued before Alice, but suspect of not meeting its standards now, be invalidated at the PTAB?

The process to invalidate a patent if the owner does not attempt to enforce it is an Inter Partes Review. They kill from 40%-70% of claims they encounter depending upon who’s method of analysis you ...
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For an appeal to the Patent Trial and Appeal Board (PTAB), what is the precise meaning of "twice rejected"?

35 U.S.C. 134 Appeal to the Patent Trial and Appeal Board. “(a) PATENT APPLICANT.— An applicant for a patent, any of whose claims has been twice rejected . . .” If the claims are completely ...
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